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Gaps matter! Could protein multiple sequence alignment gaps predict protein contacts?
(A2B2C, 2015-10-14)
Mutual Information (MI) is often used for finding covariation sites in a Multiple Sequence Alignment (MSA) and also to predict protein contacts. In Busjle et. al [1] the estimated corrected MI Z-score was calculated by ...
Conformational diversity modulates evolutionary rate in protein evolution
(A2B2C, 2011-05-10)
I-COMS: Interprotein-COrrelated Mutations Server
(A2B2C, 2015-10-14)
Several computational methods have been developed to predict protion-protein interactions from multiple sequence alignments (MSAs) in recent years. These techniques are a useful approach to help detect interfaces between ...
Mutational patterns of somatic mutations for a functional classification of human cancers
(A2B2C, 2015-10-14)
Extensive tumor genome sequencing has provided sufficient amount of data of somatic mutations. Identifying the driver mutations and their functional consequences is critical to understand cancer. Previous analysis have ...
MIToS.jl: Mutual Information Tools for prOtein Sequence analysis in Julia
(A2B2C, 2015-10-14)
Mutual Information (MI) is useful for determining covariation between positions in a Multiple Sequence Alignment (MSA). Mutual information derived scores can be useful for determining structural contacts and functional ...