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Gaps matter! Could protein multiple sequence alignment gaps predict protein contacts?
Mutual Information (MI) is often used for finding covariation sites in a Multiple Sequence Alignment (MSA) and also to predict protein contacts. In Busjle et. al  the estimated corrected MI Z-score was calculated by ...
Protein disorder promotes protein conformational diversity
In this work we studied the relationship between conformational diversity and the occurrence of protein disorder. Using 2,383 proteins with their corresponding conformers taken from CoDNaS database, we measured RMSD between ...
Conformational diversity modulates evolutionary rate in protein evolution
I-COMS: Interprotein-COrrelated Mutations Server
Several computational methods have been developed to predict protion-protein interactions from multiple sequence alignments (MSAs) in recent years. These techniques are a useful approach to help detect interfaces between ...
Mutational patterns of somatic mutations for a functional classification of human cancers
Extensive tumor genome sequencing has provided sufficient amount of data of somatic mutations. Identifying the driver mutations and their functional consequences is critical to understand cancer. Previous analysis have ...
MIToS.jl: Mutual Information Tools for prOtein Sequence analysis in Julia
Mutual Information (MI) is useful for determining covariation between positions in a Multiple Sequence Alignment (MSA). Mutual information derived scores can be useful for determining structural contacts and functional ...