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Development and comparison of stability and affinity based networks
MHC class I molecules play a central role in the immune response mediated by cytotoxic T lymphocytes (CTLs). Their specificity has made them the central focus in the development of tools for identification of immunogenic ...
BoLA (Bovine Leukocyte Antigens) class 1 typing from next-generation-sequence data
Genetic selection for disease resistance is currently of extreme interest in nearly all domestic food-producing species. Because mastitis is the most economically important disease in the dairy industry today 2, resistance ...
Prediction of peptide-MHC class II binding affinity with improved binding core identification; implications for the interpretation of T cell cross-reactivity
Prediction of peptide-MHC class II binding involves answering two questions: does the peptide bind to the MHC, and if so, where does it bind. Addressing the first question, prediction of binding affinity for MHC class II ...
Identification of receptor specific submotifs in large peptide binding data sets
MIToS.jl: Mutual Information Tools for prOtein Sequence analysis in Julia
Mutual Information (MI) is useful for determining covariation between positions in a Multiple Sequence Alignment (MSA). Mutual information derived scores can be useful for determining structural contacts and functional ...