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Local Frustration and the Energy Landscapes of Ankyrin Repeat Proteins
(A2B2C, 2015-10-14)
Protein folding is today understood within the “Energy Landscapes Theory”. In order to fold robustly, proteins must minimize their internal conflicts, following the Principle of Minimal Frustration. However, residual ...
Development and comparison of stability and affinity based networks
(A2B2C, 2015-10-14)
MHC class I molecules play a central role in the immune response mediated by cytotoxic T lymphocytes (CTLs). Their specificity has made them the central focus in the development of tools for identification of immunogenic ...
Essential dynamics of cold denaturation proteins: Model frataxin Yfh1
(A2B2C, 2015-10-14)
The transition from folding to unfolding on decreasing the temperature, is a property of globular proteins that have been considered in the literature [1-4], however the explanation of the process is still on debate. A ...
Validation and Determination of nucleic acid structures from NMR 13C chemical shifts
(A2B2C, 2015-10-14)
Nucleic acids are central molecules for the storing, flow and regulation of genetic and epigenetic information. The recent discovery of the large variety of non-coding functions of RNA molecules has renewed the interest ...
Phylogenetic and Gene/Protein Structure Analysis of Two Paralogous Kisspeptin Receptors (Kiss2R And Kiss3R) in Pejerrey (Odontesthes bonariensis)
(A2B2C, 2015-10-14)
Kisspeptin receptors play an essential role in the control of puberty in vertebrates [1-2]. In this context, we report the gene organization, the in-silico structural analysis and phylogeny of two kissr-like receptors ...
Sequence-Structure Analysis of the WD40 Protein Family
(A2B2C, 2015-10-14)
The Beta Propeller Superfold is believed to be one of the most ancient protein architectures in nature with many different families adopting this toroidal topology. We have focused this work on a very large and conservative ...
CoDNaS 2.0: a database of conformational diversity of native state in proteins
(A2B2C, 2015-10-14)
CoDNaS is a database of proteins conformers [http://www.codnas.com.ar]. Study of conformers is a key issue in protein structural biology because they describe the native state of a protein. Their study has been associated ...
Evolution and Structure-Function Prediction of Eqolisins in Fungi
(A2B2C, 2015-10-14)
Botrytis cinerea is a phytopathogenic fungus that acidifies its environment (pH<4), which has been shown to be related with the spectrum of secreted hydrolytic enzymes that are involved in the degradation of the host's ...
Protein disorder promotes protein conformational diversity
(A2B2C, 2015-10-14)
In this work we studied the relationship between conformational diversity and the occurrence of protein disorder. Using 2,383 proteins with their corresponding conformers taken from CoDNaS database, we measured RMSD between ...
Relation between dynamically relevant residues and topological networks parameters
(A2B2C, 2015-10-14)
Protein flexibility and dynamics are commonly associated with protein function. Nowadays, it is well established that the functional form of the protein, also known as the native state, is not unique. Pre-existing population ...