The alignment of protein superfamily sequences Part II: Multiple Alignment Touch-up Engine (MATE)
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Date
2015-10-14Author
Facundo Orts
Maria Victoria Revuelta
Inti A. Pagnuco
Marcel Brun
Arjen ten Have
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Show full item recordAbstract
Multiple Sequence Alignments (MSA) are crucial tools in protein bioinformatics. Despite recent advances, construction of MSAs for complex superfamilies remains problematic and requires rigorous manual correction. In this poster we present one part of our attempts to develop a protocol and, subsequently, a software that is directed at aligning many (>500) sequences of complex protein superfamilies.The output of MSA software typically consists of regions that are well aligned, regions that are poorly aligned and regions containing Cluster Specific Subsequences (CSS, See accompanying Poster Abstract by Revuelta et al.). We will describe a reproducible protocol that, once identified these regions, corrects the regions that are poorly aligned.